By: Samantha Dente
The next great frontier in medical advancements is the use of 3D printing. Although the use of 3D printing in medicine is still in its beginning stages, there are already huge implications from its use.
Most recently in September, a cancer patient received a 3D printed titanium sternum and partial rib cage to replace the bones he had lost during cancer treatment.[1] Compared to traditional flat plate implants, which tend to loosen over time and thus require follow up invasive procedures for maintenance or replacement, the success of the surgery marks a breakthrough in the medical community.[2] In addition to the more durable material, another benefit of 3D printed implants is that the implant can be made to resemble the patient’s actual anatomy with the aid of CT scans.[3]
In August, another breakthrough occurred when the FDA approved a 3D printed prescription pill for consumer use to treat epilepsy.[4] The 3D technology allows pills to be made more porous which allows them to dissolve faster and thus act quicker.[5] Before that, in 2013, a two-year-old girl born without a trachea received a 3D printed windpipe built with her own stem cells. [6]
One of the biggest areas of concern is how the use of 3D printing will change research and development (R&D) for medical device manufacturers and pharmaceutical companies.[7] One of the foreseeable functions 3D printing is the ability to print tissues and organs for drug testing, which would in turn eliminate the need for animal testing or synthetic models which are less accurate.[8] Currently, the average R&D cost for a new drug is approximately $4 billion and the failure rate of drugs in clinical trials is 90% due to differing animal and human responses to testing.[9] By lowering the risk of trial failure, this would lead to a reduction of cost and clinical trial failures.
In 2013, the U.S. funded the “Body on a Chip†project, and just this year the first organ chips are coming to market.[10] In an effort to curb the issues with R&D described above, the project encouraged universities to essentially 3D print organs through the following process: prints of sample tissue meant to mimic human organs are placed on a microchip and connected with a blood substitute to keep cells alive. [11] This allows doctors to more accurately test specific treatments and monitor their effectiveness.[12] The military has shown interest in this project in the hopes of one day developing treatments for nuclear and biological incidents and has funded about $39 million into projects at Harvard and MIT.[13]
Although there was concern over FDA roadblocks, it has surprisingly expressed openness to the use 3D printing in R&D.[14]
It has been about thirty years since 3D printing technology was first introduced, and the biotechnology community is finally harnessing its true power and potential.[15] It has been predicted that patients eventually may be able to print their own medicines at home, which would in turn lead to a transition in how medications are prescribed.[16] It may seem like science fiction, but it is a possibility that could become a reality sooner than we think.
[1] Kelly Hodgkins, Cancer Patient Undergoes World’s First 3D Printed Sternum Replacement Surgery, Digital Trends (Sep. 11, 2015), http://www.digitaltrends.com/cool-tech/sternum-ribs-3d-print-implant/.
[2] Id.
[3] Id.
[4] Dominic Basulto, Why It Matters That the FDA Just Approved The First 3D Printed Drug, The Washington Post (Aug. 11, 2015), https://www.washingtonpost.com/news/innovations/wp/2015/08/11/why-it-matters-that-the-fda-just-approved-the-first-3d-printed-drug/.
[5] Id.
[6] Zuzanna Fiminska, 3D Printing Set To Revolutionize Pharma, Eye For Pharma (July 15, 2014), http://social.eyeforpharma.com/clinical/3d-printing-set-revolutionize-pharma.
[7] Id.
[8] Id.
[9] Id.
[10] Towards a Body-On-A-Chip, The Economist (Jun 13, 2015), http://www.economist.com/news/science-and-technology/21654013-first-organ-chips-are-coming-market-and-regulators-permitting-will-speed.
[11] Fiminska, supra note 6.
[12] Id.
[13] Towards a Body-On-A-Chip, supra note 10.
[14] Basulto, supra note 4.
[15] Bethany Gross, Evaluation of 3D Printing and Its Potential Impact on Biotechnology and Chemical Sciences, Analytical Chemistry (Jan. 16, 2014), http://pubs.acs.org/doi/pdf/10.1021/ac403397r.
[16] Basulto, supra note 4.